World number one Roger Federer will face Chile's Fernando Gonzalez as he bids to join Rafael Nadal and Novak Djokovic in the semi-finals of the French Open.
The Swiss top seed has been shunted onto Court Suzanne Lenglen with Centre Court honours going to local favourite Gael Monfils, who will take on Spanish fifth seed David Ferrer in the other quarter-final in the top half of the draw.
Federer should advance having lost only once in 11 meetings with the Chilean, but that one defeat came in their last encounter at the Masters Cup in Shanghai in 2007.
Monfils will be hoping to become the first Frenchman to reach the last four at Roland Garros since Sebastien Grosjean in 2001.
Seventh seed Elena Dementieva, a finalist on the Paris clay in 2004, will open proceedings on the main court in an all-Russian clash with 13th seed Dinara Safina, who knocked out world number one Maria Sharapova in the previous round.
Russian fourth seed Svetlana Kuznetsova faces a first career meeting against unseeded Kaia Kanepi, the first Estonian singles player to reach the quarters of a Grand Slam.
Quarter final (set)
13:00 Safina D. v Dementieva E.
13:00 Kuznetsova S. v Kanepi K.
15:00 Federer R. v Gonzalez F.
15:00 Monfils G. v Ferrer D.